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SD PATHOLOGY

FSH, LH &Prolactin

FSH, LH &Prolactin

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What is FSH, LH & Prolactin?

The Hormonal Profile Test, encompassing Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), and Prolactin, assesses the levels of key hormones that help regulate reproductive functions and lactation. The test is vital for detecting and monitoring hormonal disorders and fertility issues.

FSH, LH, and prolactin are all produced in the anterior pituitary gland and play vital roles in reproductive health and overall well-being. Assessing their levels with this hormonal panel is often the first step in determining fertility in both men and women.

FSH is crucial for the development of eggs, regulation of menstrual cycles in females, and sperm production in males. LH encourages the release of an egg from the ovary in females and stimulates testosterone production in males. Abnormal levels of FSH and LH can indicate menstrual irregularity, fertility issues, and conditions such as polycystic ovary syndrome (PCOS) and pituitary disorders.

Prolactin is a hormone that stimulates breast development and milk production (lactation) in females. Additionally, it also influences the menstrual cycle. Elevated prolactin levels can interfere with fertility, cause menstrual irregularities, and be associated with conditions such as galactorrhea (inappropriate milk production) and pituitary tumors (prolactinomas).

In women, the doctor may suggest this test in case of symptoms of irregular or heavy menstrual periods, PCOS/PCOD, if you are facing difficulty in getting pregnant, and/or if pituitary or hypothalamus problems are suspected. In men, this test can be performed when fertility issues and signs of low testosterone levels, such as decreased sex drive and low muscle mass, are observed. 

Overnight fasting is required for this hormonal profile. Do not eat or drink anything other than water for 8-12 hours before the test. In women, the preferred time to collect the sample is the second or third day of the menstrual cycle. Your doctor may ask you to temporarily stop taking certain medications, such as birth control pills or Biotin (Vitamin B7) supplements, as they may lead to some aberrancy in your test results. Prolactin levels can vary throughout the day as prolactin is secreted episodically and may be influenced by factors such as stress, exercise, and sleep. Therefore, multiple prolactin tests may be needed to confirm the diagnosis.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help them determine your medical condition and formulate your treatment plan.

What is FSH, LH & Prolactin used for?

An FSH, LH & Prolactin test is done:

  • Evaluate infertility issues in males and females.
  • Assess menstrual irregularities and conditions such as amenorrhea or oligomenorrhea.
  • Investigate the cause of abnormal breast milk discharge (galactorrhea) in non-pregnant women.
  • Evaluate the role of prolactin in case of lactation failure in women after childbirth.
  • Diagnose disorders or tumors of the pituitary gland or diseases involving the testes or ovaries.

What does FSH, LH & Prolactin measure?

Contains 3 tests

An FSH, LH & Prolactin test measures levels of three hormones, namely follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin, that are critical for reproductive function in males and females. This hormonal test is conducted to address various issues associated with the process of ovulation, fertility, and reproductive organs.

The levels of these hormones are typically low at younger ages, but as adolescence approaches, the brain starts producing GnRH. GnRH is responsible for initiating the changes in puberty and signaling the pituitary gland to release FSH and LH into your blood.

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Follicle Stimulating Hormone

 

 


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Serum Prolactin

 

 

 

 


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Luteinising Hormone

 

 

Interpreting FSH, LH & Prolactin results


Interpretations

The reference range of FSH is age- and gender-specific. As for women, the reference range is phase-specific for the menstrual cycle.

The reference range for follicle-stimulating hormone (FSH) is as follows (3rd generation immunochemiluminescence assay):

Females 

·       Age 0-7 years: <6.7 mIU/mL

·       Age 8 years to adult:

·       Follicular phase: 3.1-7.9 mIU/mL

·       Ovulation peak: 2.3-18.5 mIU/mL

·       Luteal phase: 1.4-5.5 mIU/mL

·       Postmenopausal: 30.6-106.3 mIU/mL

Males

·       Age 0-7 years: <6.7 mIU/mL

·       Age 8 years-adult:1.3-19.3 mIU/mL

The following values are considered to be normal, LH blood levels measured in international units per liter (IU/L):

Women:

·       Follicular phase of the menstrual cycle: 1.9 to 12.5 IU/L

·       LH surge: 8.7 to 76.3 IU/L

·       Luteal phase of the menstrual cycle: 0.5 to 16.9 IU/L

·       Pregnancy: less than 1.5 IU/L

·       Post-menopause: 15.9 to 54.0 IU/L

·       Women using contraceptives: 0.7 to 5.6 IU/L

Men:

·       Age group of 20 and 70 years: 0.7 to 7.9 IU/L

·       >70 years of age: 3.1 to 34.0 IU/L

The following values are considered to be normal, prolactin blood levels measured in international units per liter (ng/mL):

Patients (Age)                                           Reference Range(s)

Males ≤ 18 Years

 

  Tanner Stage 1 (< 9.8 Years)    

  Tanner Stage 2 (9.8 - 14.5 Years) 

  Tanner Stage 3 (10.7 - 15.4 Years)  

  Tanner Stage 4 (11.8 - 16.2 Years)   

  Tanner Stage 5 (12.8 - 17.3 Years)    


Males > 18 Years

                   

< 10 ng/mL

< 6.1 ng/mL 

< 6.1 ng/mL

   2.8 - 11.0 ng/mL

   2.8 - 11.0 ng/mL

  

    2.10 - 17.70 ng/mL

In Females ≤ 18 Years

 

  Tanner Stage I (< 9.2 Years)

3.6 - 12.0 ng/mL

  Tanner Stage 2 (9.2 - 13.7 Years)

2.6 - 18.0 ng/mL

  Tanner Stage 3 (10 - 14.4 Years)

2.6 - 18.0 ng/mL

  Tanner Stage 4 (10.7 - 15.6 Years)

3.2 - 20.0 ng/mL

  Tanner Stage 5 (11.8 - 18.6 Years)

3.2 - 20.0 ng/mL

Adult Females

  Non Pregnant                                             


2.80 - 29.20 ng/mL

  Pregnant  

  Post Menopausal

9.70 - 208.50 ng/mL

1.80 - 20.30 ng/mL

The reference range may vary from lab to lab*

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about FSH, LH & Prolactin


Frequently Asked Questions about FSH, LH & Prolactin

Q. Why is an FSH, LH & Prolactin test done?

An FSH, LH & Prolactin test is done to assess the levels of hormones FSH, LH, and Prolactin that are essential for understanding reproductive health and fertility in both men and women.

Q. What are the symptoms of hormonal imbalance in men and women?

Women with hormonal imbalances often experience heavy or irregular periods, mood swings, raised blood sugar levels, bloating, fatigue, excessive facial hair growth, and unexplained weight changes. On the other hand, men with hormonal imbalances may experience hair thinning, hair loss, weight gain/loss, low sex drive, erectile dysfunction, fatigue, and depression, and show poor semen parameters, including low sperm count, motility, and morphology, leading to infertility. Consult your doctor to get a better understanding of your hormonal status.
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